Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity

Objective(s)To determine whether women with diminished ovarian reserve (DOR) (quantitatively) had lower rates of euploid blastocysts, as a proxy for oocyte quality.DesignRetrospective cohort study.SettingUniversity reproductive health clinic.Patient(s)A total 1,152 aged 19–42 years underwent 1,675 IVF cycles yielding 8,073 blastocysts biopsy from 2010 to 2019.Interventions(s)Preimplantation genetic testing aneuploidy.Main Outcome Measure(s)Euploid rates, defined the number divided by biopsied per cycle.Result(s)A 225 (20%) DOR infertility diagnosis Bologna criteria. Age was higher among (39.5 y vs. 37.0 y). Euploid were without (29.0% 44.9%). In generalized linear models controlling age, 24% reduced odds blastocyst being versus DOR. secondary analysis assigning status producing lowest quartile age-adjusted mature yield, this relationship remained. No differences identified in live birth between and after single-embryo transfer independently age (n = 944 transfers; 56.8% 54.8%, respectively).Conclusion(s)Blastocysts are less likely be than those adjustment age. Given concomitant reduction quantity oocytes observed study, quantitative assessments (i.e., follicular machinery) may yield insight into relative aging. To quality. Retrospective study. University clinic. A 2019. Preimplantation aneuploidy. cycle. respectively). Blastocysts